diff --git a/arch/Kconfig b/arch/Kconfig
index 5f8a5d84dbbe..d5ca838ae8ad 100644
--- a/arch/Kconfig
+++ b/arch/Kconfig
@@ -843,7 +843,7 @@ config HAVE_ARCH_VMAP_STACK
 config VMAP_STACK
 	default y
 	bool "Use a virtually-mapped stack"
-	depends on HAVE_ARCH_VMAP_STACK && !KASAN
+	depends on HAVE_ARCH_VMAP_STACK && !KASAN && !KMSAN
 	---help---
 	  Enable this if you want the use virtually-mapped kernel stacks
 	  with guard pages.  This causes kernel stack overflows to be
diff --git a/arch/x86/Kconfig b/arch/x86/Kconfig
index 3f83a5c53808..6d2b0fb3a871 100644
--- a/arch/x86/Kconfig
+++ b/arch/x86/Kconfig
@@ -2143,6 +2143,7 @@ config RELOCATABLE
 config RANDOMIZE_BASE
 	bool "Randomize the address of the kernel image (KASLR)"
 	depends on RELOCATABLE
+	depends on !KMSAN
 	default y
 	---help---
 	  In support of Kernel Address Space Layout Randomization (KASLR),
diff --git a/arch/x86/Kconfig.debug b/arch/x86/Kconfig.debug
index bf9cd83de777..db3cd6147829 100644
--- a/arch/x86/Kconfig.debug
+++ b/arch/x86/Kconfig.debug
@@ -292,6 +292,9 @@ choice
 config UNWINDER_ORC
 	bool "ORC unwinder"
 	depends on X86_64
+	# KMSAN doesn't support UNWINDER_ORC yet,
+	# see https://github.com/google/kmsan/issues/48.
+	depends on !KMSAN
 	select STACK_VALIDATION
 	---help---
 	  This option enables the ORC (Oops Rewind Capability) unwinder for
diff --git a/crypto/Kconfig b/crypto/Kconfig
index 9e524044d312..37a22711012c 100644
--- a/crypto/Kconfig
+++ b/crypto/Kconfig
@@ -309,11 +309,13 @@ config CRYPTO_AEGIS128
 config CRYPTO_AEGIS128_SIMD
 	bool "Support SIMD acceleration for AEGIS-128"
 	depends on CRYPTO_AEGIS128 && ((ARM || ARM64) && KERNEL_MODE_NEON)
+	depends on !KMSAN
 	default y
 
 config CRYPTO_AEGIS128_AESNI_SSE2
 	tristate "AEGIS-128 AEAD algorithm (x86_64 AESNI+SSE2 implementation)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_AEAD
 	select CRYPTO_SIMD
 	help
@@ -571,6 +573,7 @@ config CRYPTO_CRC32C
 config CRYPTO_CRC32C_INTEL
 	tristate "CRC32c INTEL hardware acceleration"
 	depends on X86
+	depends on !KMSAN
 	select CRYPTO_HASH
 	help
 	  In Intel processor with SSE4.2 supported, the processor will
@@ -611,6 +614,7 @@ config CRYPTO_CRC32
 config CRYPTO_CRC32_PCLMUL
 	tristate "CRC32 PCLMULQDQ hardware acceleration"
 	depends on X86
+	depends on !KMSAN
 	select CRYPTO_HASH
 	select CRC32
 	help
@@ -649,6 +653,7 @@ config CRYPTO_CRCT10DIF
 config CRYPTO_CRCT10DIF_PCLMUL
 	tristate "CRCT10DIF PCLMULQDQ hardware acceleration"
 	depends on X86 && 64BIT && CRC_T10DIF
+	depends on !KMSAN
 	select CRYPTO_HASH
 	help
 	  For x86_64 processors with SSE4.2 and PCLMULQDQ supported,
@@ -695,6 +700,7 @@ config CRYPTO_POLY1305
 config CRYPTO_POLY1305_X86_64
 	tristate "Poly1305 authenticator algorithm (x86_64/SSE2/AVX2)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_POLY1305
 	help
 	  Poly1305 authenticator algorithm, RFC7539.
@@ -814,6 +820,7 @@ config CRYPTO_SHA1
 config CRYPTO_SHA1_SSSE3
 	tristate "SHA1 digest algorithm (SSSE3/AVX/AVX2/SHA-NI)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_SHA1
 	select CRYPTO_HASH
 	help
@@ -825,6 +832,7 @@ config CRYPTO_SHA1_SSSE3
 config CRYPTO_SHA256_SSSE3
 	tristate "SHA256 digest algorithm (SSSE3/AVX/AVX2/SHA-NI)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_SHA256
 	select CRYPTO_HASH
 	help
@@ -837,6 +845,7 @@ config CRYPTO_SHA256_SSSE3
 config CRYPTO_SHA512_SSSE3
 	tristate "SHA512 digest algorithm (SSSE3/AVX/AVX2)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_SHA512
 	select CRYPTO_HASH
 	help
@@ -1011,6 +1020,7 @@ config CRYPTO_WP512
 config CRYPTO_GHASH_CLMUL_NI_INTEL
 	tristate "GHASH hash function (CLMUL-NI accelerated)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_CRYPTD
 	help
 	  This is the x86_64 CLMUL-NI accelerated implementation of
@@ -1064,6 +1074,7 @@ config CRYPTO_AES_TI
 config CRYPTO_AES_NI_INTEL
 	tristate "AES cipher algorithms (AES-NI)"
 	depends on X86
+	depends on !KMSAN
 	select CRYPTO_AEAD
 	select CRYPTO_LIB_AES
 	select CRYPTO_ALGAPI
@@ -1190,6 +1201,7 @@ config CRYPTO_BLOWFISH_COMMON
 config CRYPTO_BLOWFISH_X86_64
 	tristate "Blowfish cipher algorithm (x86_64)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_BLOWFISH_COMMON
 	help
@@ -1221,6 +1233,7 @@ config CRYPTO_CAMELLIA_X86_64
 	tristate "Camellia cipher algorithm (x86_64)"
 	depends on X86 && 64BIT
 	depends on CRYPTO
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_GLUE_HELPER_X86
 	help
@@ -1238,6 +1251,7 @@ config CRYPTO_CAMELLIA_AESNI_AVX_X86_64
 	tristate "Camellia cipher algorithm (x86_64/AES-NI/AVX)"
 	depends on X86 && 64BIT
 	depends on CRYPTO
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_CAMELLIA_X86_64
 	select CRYPTO_GLUE_HELPER_X86
@@ -1258,6 +1272,7 @@ config CRYPTO_CAMELLIA_AESNI_AVX2_X86_64
 	tristate "Camellia cipher algorithm (x86_64/AES-NI/AVX2)"
 	depends on X86 && 64BIT
 	depends on CRYPTO
+	depends on !KMSAN
 	select CRYPTO_CAMELLIA_AESNI_AVX_X86_64
 	help
 	  Camellia cipher algorithm module (x86_64/AES-NI/AVX2).
@@ -1303,6 +1318,7 @@ config CRYPTO_CAST5
 config CRYPTO_CAST5_AVX_X86_64
 	tristate "CAST5 (CAST-128) cipher algorithm (x86_64/AVX)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_CAST5
 	select CRYPTO_CAST_COMMON
@@ -1325,6 +1341,7 @@ config CRYPTO_CAST6
 config CRYPTO_CAST6_AVX_X86_64
 	tristate "CAST6 (CAST-256) cipher algorithm (x86_64/AVX)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_CAST6
 	select CRYPTO_CAST_COMMON
@@ -1360,6 +1377,7 @@ config CRYPTO_DES_SPARC64
 config CRYPTO_DES3_EDE_X86_64
 	tristate "Triple DES EDE cipher algorithm (x86-64)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_LIB_DES
 	help
@@ -1426,6 +1444,7 @@ config CRYPTO_CHACHA20
 config CRYPTO_CHACHA20_X86_64
 	tristate "ChaCha stream cipher algorithms (x86_64/SSSE3/AVX2/AVX-512VL)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_CHACHA20
 	help
@@ -1462,6 +1481,7 @@ config CRYPTO_SERPENT
 config CRYPTO_SERPENT_SSE2_X86_64
 	tristate "Serpent cipher algorithm (x86_64/SSE2)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_GLUE_HELPER_X86
 	select CRYPTO_SERPENT
@@ -1481,6 +1501,7 @@ config CRYPTO_SERPENT_SSE2_X86_64
 config CRYPTO_SERPENT_SSE2_586
 	tristate "Serpent cipher algorithm (i586/SSE2)"
 	depends on X86 && !64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_GLUE_HELPER_X86
 	select CRYPTO_SERPENT
@@ -1500,6 +1521,7 @@ config CRYPTO_SERPENT_SSE2_586
 config CRYPTO_SERPENT_AVX_X86_64
 	tristate "Serpent cipher algorithm (x86_64/AVX)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_GLUE_HELPER_X86
 	select CRYPTO_SERPENT
@@ -1520,6 +1542,7 @@ config CRYPTO_SERPENT_AVX_X86_64
 config CRYPTO_SERPENT_AVX2_X86_64
 	tristate "Serpent cipher algorithm (x86_64/AVX2)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_SERPENT_AVX_X86_64
 	help
 	  Serpent cipher algorithm, by Anderson, Biham & Knudsen.
@@ -1615,6 +1638,7 @@ config CRYPTO_TWOFISH_586
 config CRYPTO_TWOFISH_X86_64
 	tristate "Twofish cipher algorithm (x86_64)"
 	depends on (X86 || UML_X86) && 64BIT
+	depends on !KMSAN
 	select CRYPTO_ALGAPI
 	select CRYPTO_TWOFISH_COMMON
 	help
@@ -1631,6 +1655,7 @@ config CRYPTO_TWOFISH_X86_64
 config CRYPTO_TWOFISH_X86_64_3WAY
 	tristate "Twofish cipher algorithm (x86_64, 3-way parallel)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_TWOFISH_COMMON
 	select CRYPTO_TWOFISH_X86_64
@@ -1652,6 +1677,7 @@ config CRYPTO_TWOFISH_X86_64_3WAY
 config CRYPTO_TWOFISH_AVX_X86_64
 	tristate "Twofish cipher algorithm (x86_64/AVX)"
 	depends on X86 && 64BIT
+	depends on !KMSAN
 	select CRYPTO_BLKCIPHER
 	select CRYPTO_GLUE_HELPER_X86
 	select CRYPTO_SIMD
diff --git a/drivers/gpu/drm/amd/display/Kconfig b/drivers/gpu/drm/amd/display/Kconfig
index 71991a28a775..99585eaf4dd0 100644
--- a/drivers/gpu/drm/amd/display/Kconfig
+++ b/drivers/gpu/drm/amd/display/Kconfig
@@ -6,7 +6,7 @@ config DRM_AMD_DC
 	bool "AMD DC - Enable new display engine"
 	default y
 	select SND_HDA_COMPONENT if SND_HDA_CORE
-	select DRM_AMD_DC_DCN1_0 if X86 && !(KCOV_INSTRUMENT_ALL && KCOV_ENABLE_COMPARISONS)
+	select DRM_AMD_DC_DCN1_0 if X86 && !(KCOV_INSTRUMENT_ALL && KCOV_ENABLE_COMPARISONS) && !KMSAN
 	help
 	  Choose this option if you want to use the new display engine
 	  support for AMDGPU. This adds required support for Vega and
diff --git a/lib/Kconfig.debug b/lib/Kconfig.debug
index 75c36318943d..a3f6f5d68593 100644
--- a/lib/Kconfig.debug
+++ b/lib/Kconfig.debug
@@ -1068,6 +1068,9 @@ menu "Lock Debugging (spinlocks, mutexes, etc...)"
 config LOCK_DEBUGGING_SUPPORT
 	bool
 	depends on TRACE_IRQFLAGS_SUPPORT && STACKTRACE_SUPPORT && LOCKDEP_SUPPORT
+	# KMSAN is incompatible with lockdep,
+	# see https://github.com/google/kmsan/issues/57.
+	depends on !KMSAN
 	default y
 
 config PROVE_LOCKING
