diff --git a/arch/x86/boot/Makefile b/arch/x86/boot/Makefile
index e2839b5c246c..c039abd4c81f 100644
--- a/arch/x86/boot/Makefile
+++ b/arch/x86/boot/Makefile
@@ -10,6 +10,8 @@
 #
 
 KASAN_SANITIZE			:= n
+# KMSAN doesn't work for i386
+KMSAN_SANITIZE			:= n
 OBJECT_FILES_NON_STANDARD	:= y
 
 # Kernel does not boot with kcov instrumentation here.
diff --git a/arch/x86/boot/compressed/Makefile b/arch/x86/boot/compressed/Makefile
index 6b84afdd7538..9efe2d9fca4c 100644
--- a/arch/x86/boot/compressed/Makefile
+++ b/arch/x86/boot/compressed/Makefile
@@ -18,6 +18,8 @@
 #	compressed vmlinux.bin.all + u32 size of vmlinux.bin.all
 
 KASAN_SANITIZE			:= n
+# KMSAN doesn't work for i386
+KMSAN_SANITIZE			:= n
 OBJECT_FILES_NON_STANDARD	:= y
 
 # Prevents link failures: __sanitizer_cov_trace_pc() is not linked in.
diff --git a/arch/x86/entry/vdso/Makefile b/arch/x86/entry/vdso/Makefile
index 0f2154106d01..000467a1a4f2 100644
--- a/arch/x86/entry/vdso/Makefile
+++ b/arch/x86/entry/vdso/Makefile
@@ -11,6 +11,9 @@ include $(srctree)/lib/vdso/Makefile
 
 KBUILD_CFLAGS += $(DISABLE_LTO)
 KASAN_SANITIZE			:= n
+# Undefined references to KMSAN hooks.
+KMSAN_SANITIZE_vclock_gettime.o := n
+KMSAN_SANITIZE_vgetcpu.o	:= n
 UBSAN_SANITIZE			:= n
 OBJECT_FILES_NON_STANDARD	:= y
 
diff --git a/arch/x86/kernel/Makefile b/arch/x86/kernel/Makefile
index 3578ad248bc9..ce39972a7edf 100644
--- a/arch/x86/kernel/Makefile
+++ b/arch/x86/kernel/Makefile
@@ -28,6 +28,10 @@ KASAN_SANITIZE_dumpstack_$(BITS).o			:= n
 KASAN_SANITIZE_stacktrace.o				:= n
 KASAN_SANITIZE_paravirt.o				:= n
 
+# Work around reboot loop.
+KMSAN_SANITIZE_head$(BITS).o				:= n
+KMSAN_SANITIZE_nmi.o					:= n
+
 OBJECT_FILES_NON_STANDARD_relocate_kernel_$(BITS).o	:= y
 OBJECT_FILES_NON_STANDARD_test_nx.o			:= y
 OBJECT_FILES_NON_STANDARD_paravirt_patch.o		:= y
diff --git a/arch/x86/kernel/cpu/Makefile b/arch/x86/kernel/cpu/Makefile
index d7a1e5a9331c..41f4f8f2f2f0 100644
--- a/arch/x86/kernel/cpu/Makefile
+++ b/arch/x86/kernel/cpu/Makefile
@@ -12,6 +12,7 @@ endif
 # If these files are instrumented, boot hangs during the first second.
 KCOV_INSTRUMENT_common.o := n
 KCOV_INSTRUMENT_perf_event.o := n
+KMSAN_SANITIZE_common.o := n
 
 # Make sure load_percpu_segment has no stackprotector
 nostackp := $(call cc-option, -fno-stack-protector)
diff --git a/arch/x86/mm/Makefile b/arch/x86/mm/Makefile
index 84373dc9b341..42cb3a6409b0 100644
--- a/arch/x86/mm/Makefile
+++ b/arch/x86/mm/Makefile
@@ -7,6 +7,8 @@ KCOV_INSTRUMENT_mem_encrypt_identity.o	:= n
 KASAN_SANITIZE_mem_encrypt.o		:= n
 KASAN_SANITIZE_mem_encrypt_identity.o	:= n
 
+KMSAN_SANITIZE_cpu_entry_area.o := n
+
 ifdef CONFIG_FUNCTION_TRACER
 CFLAGS_REMOVE_mem_encrypt.o		= -pg
 CFLAGS_REMOVE_mem_encrypt_identity.o	= -pg
diff --git a/arch/x86/realmode/rm/Makefile b/arch/x86/realmode/rm/Makefile
index f60501a384f9..27e7bc0bbdde 100644
--- a/arch/x86/realmode/rm/Makefile
+++ b/arch/x86/realmode/rm/Makefile
@@ -7,6 +7,8 @@
 #
 #
 KASAN_SANITIZE			:= n
+# KMSAN doesn't work for i386
+KMSAN_SANITIZE			:= n
 OBJECT_FILES_NON_STANDARD	:= y
 
 # Prevents link failures: __sanitizer_cov_trace_pc() is not linked in.
diff --git a/drivers/firmware/efi/libstub/Makefile b/drivers/firmware/efi/libstub/Makefile
index 0460c7581220..11869c17a64c 100644
--- a/drivers/firmware/efi/libstub/Makefile
+++ b/drivers/firmware/efi/libstub/Makefile
@@ -32,6 +32,7 @@ KBUILD_CFLAGS			:= $(cflags-y) -DDISABLE_BRANCH_PROFILING \
 
 GCOV_PROFILE			:= n
 KASAN_SANITIZE			:= n
+KMSAN_SANITIZE			:= n
 UBSAN_SANITIZE			:= n
 OBJECT_FILES_NON_STANDARD	:= y
 
diff --git a/kernel/Makefile b/kernel/Makefile
index daad787fb795..5fd6fbca2592 100644
--- a/kernel/Makefile
+++ b/kernel/Makefile
@@ -30,6 +30,7 @@ KCOV_INSTRUMENT_extable.o := n
 # Don't self-instrument.
 KCOV_INSTRUMENT_kcov.o := n
 KASAN_SANITIZE_kcov.o := n
+KMSAN_SANITIZE_kcov.o := n
 CFLAGS_kcov.o := $(call cc-option, -fno-conserve-stack -fno-stack-protector)
 
 # cond_syscall is currently not LTO compatible
diff --git a/lib/Makefile b/lib/Makefile
index 08fcb37499a0..ae6e57d857b0 100644
--- a/lib/Makefile
+++ b/lib/Makefile
@@ -222,6 +222,7 @@ obj-$(CONFIG_IRQ_POLL) += irq_poll.o
 CFLAGS_stackdepot.o += -fno-builtin
 obj-$(CONFIG_STACKDEPOT) += stackdepot.o
 KASAN_SANITIZE_stackdepot.o := n
+KMSAN_SANITIZE_stackdepot.o := n
 KCOV_INSTRUMENT_stackdepot.o := n
 
 libfdt_files = fdt.o fdt_ro.o fdt_wip.o fdt_rw.o fdt_sw.o fdt_strerror.o \
