diff --git a/arch/x86/lib/iomem.c b/arch/x86/lib/iomem.c
index df50451d94ef7..2307770f3f4c8 100644
--- a/arch/x86/lib/iomem.c
+++ b/arch/x86/lib/iomem.c
@@ -1,6 +1,7 @@
 #include <linux/string.h>
 #include <linux/module.h>
 #include <linux/io.h>
+#include <linux/kmsan-checks.h>
 
 #define movs(type,to,from) \
 	asm volatile("movs" type:"=&D" (to), "=&S" (from):"0" (to), "1" (from):"memory")
@@ -37,6 +38,8 @@ void memcpy_fromio(void *to, const volatile void __iomem *from, size_t n)
 		n-=2;
 	}
 	rep_movs(to, (const void *)from, n);
+	/* KMSAN must treat values read from devices as initialized. */
+	kmsan_unpoison_memory(to, n);
 }
 EXPORT_SYMBOL(memcpy_fromio);
 
@@ -45,6 +48,8 @@ void memcpy_toio(volatile void __iomem *to, const void *from, size_t n)
 	if (unlikely(!n))
 		return;
 
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(from, n);
 	/* Align any unaligned destination IO */
 	if (unlikely(1 & (unsigned long)to)) {
 		movs("b", to, from);
diff --git a/lib/iomap.c b/lib/iomap.c
index fbaa3e8f19d6c..bdda1a42771b2 100644
--- a/lib/iomap.c
+++ b/lib/iomap.c
@@ -6,6 +6,7 @@
  */
 #include <linux/pci.h>
 #include <linux/io.h>
+#include <linux/kmsan-checks.h>
 
 #include <linux/export.h>
 
@@ -70,26 +71,31 @@ static void bad_io_access(unsigned long port, const char *access)
 #define mmio_read64be(addr) swab64(readq(addr))
 #endif
 
+__no_sanitize_memory
 unsigned int ioread8(const void __iomem *addr)
 {
 	IO_COND(addr, return inb(port), return readb(addr));
 	return 0xff;
 }
+__no_sanitize_memory
 unsigned int ioread16(const void __iomem *addr)
 {
 	IO_COND(addr, return inw(port), return readw(addr));
 	return 0xffff;
 }
+__no_sanitize_memory
 unsigned int ioread16be(const void __iomem *addr)
 {
 	IO_COND(addr, return pio_read16be(port), return mmio_read16be(addr));
 	return 0xffff;
 }
+__no_sanitize_memory
 unsigned int ioread32(const void __iomem *addr)
 {
 	IO_COND(addr, return inl(port), return readl(addr));
 	return 0xffffffff;
 }
+__no_sanitize_memory
 unsigned int ioread32be(const void __iomem *addr)
 {
 	IO_COND(addr, return pio_read32be(port), return mmio_read32be(addr));
@@ -142,18 +148,21 @@ static u64 pio_read64be_hi_lo(unsigned long port)
 	return lo | (hi << 32);
 }
 
+__no_sanitize_memory
 u64 ioread64_lo_hi(const void __iomem *addr)
 {
 	IO_COND(addr, return pio_read64_lo_hi(port), return readq(addr));
 	return 0xffffffffffffffffULL;
 }
 
+__no_sanitize_memory
 u64 ioread64_hi_lo(const void __iomem *addr)
 {
 	IO_COND(addr, return pio_read64_hi_lo(port), return readq(addr));
 	return 0xffffffffffffffffULL;
 }
 
+__no_sanitize_memory
 u64 ioread64be_lo_hi(const void __iomem *addr)
 {
 	IO_COND(addr, return pio_read64be_lo_hi(port),
@@ -161,6 +170,7 @@ u64 ioread64be_lo_hi(const void __iomem *addr)
 	return 0xffffffffffffffffULL;
 }
 
+__no_sanitize_memory
 u64 ioread64be_hi_lo(const void __iomem *addr)
 {
 	IO_COND(addr, return pio_read64be_hi_lo(port),
@@ -188,22 +198,32 @@ EXPORT_SYMBOL(ioread64be_hi_lo);
 
 void iowrite8(u8 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, outb(val,port), writeb(val, addr));
 }
 void iowrite16(u16 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, outw(val,port), writew(val, addr));
 }
 void iowrite16be(u16 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, pio_write16be(val,port), mmio_write16be(val, addr));
 }
 void iowrite32(u32 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, outl(val,port), writel(val, addr));
 }
 void iowrite32be(u32 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, pio_write32be(val,port), mmio_write32be(val, addr));
 }
 EXPORT_SYMBOL(iowrite8);
@@ -239,24 +259,32 @@ static void pio_write64be_hi_lo(u64 val, unsigned long port)
 
 void iowrite64_lo_hi(u64 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, pio_write64_lo_hi(val, port),
 		writeq(val, addr));
 }
 
 void iowrite64_hi_lo(u64 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, pio_write64_hi_lo(val, port),
 		writeq(val, addr));
 }
 
 void iowrite64be_lo_hi(u64 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, pio_write64be_lo_hi(val, port),
 		mmio_write64be(val, addr));
 }
 
 void iowrite64be_hi_lo(u64 val, void __iomem *addr)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(&val, sizeof(val));
 	IO_COND(addr, pio_write64be_hi_lo(val, port),
 		mmio_write64be(val, addr));
 }
@@ -328,14 +356,20 @@ static inline void mmio_outsl(void __iomem *addr, const u32 *src, int count)
 void ioread8_rep(const void __iomem *addr, void *dst, unsigned long count)
 {
 	IO_COND(addr, insb(port,dst,count), mmio_insb(addr, dst, count));
+	/* KMSAN must treat values read from devices as initialized. */
+	kmsan_unpoison_memory(dst, count);
 }
 void ioread16_rep(const void __iomem *addr, void *dst, unsigned long count)
 {
 	IO_COND(addr, insw(port,dst,count), mmio_insw(addr, dst, count));
+	/* KMSAN must treat values read from devices as initialized. */
+	kmsan_unpoison_memory(dst, count * 2);
 }
 void ioread32_rep(const void __iomem *addr, void *dst, unsigned long count)
 {
 	IO_COND(addr, insl(port,dst,count), mmio_insl(addr, dst, count));
+	/* KMSAN must treat values read from devices as initialized. */
+	kmsan_unpoison_memory(dst, count * 4);
 }
 EXPORT_SYMBOL(ioread8_rep);
 EXPORT_SYMBOL(ioread16_rep);
@@ -343,14 +377,20 @@ EXPORT_SYMBOL(ioread32_rep);
 
 void iowrite8_rep(void __iomem *addr, const void *src, unsigned long count)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(src, count);
 	IO_COND(addr, outsb(port, src, count), mmio_outsb(addr, src, count));
 }
 void iowrite16_rep(void __iomem *addr, const void *src, unsigned long count)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(src, count * 2);
 	IO_COND(addr, outsw(port, src, count), mmio_outsw(addr, src, count));
 }
 void iowrite32_rep(void __iomem *addr, const void *src, unsigned long count)
 {
+	/* Make sure uninitialized memory isn't copied to devices. */
+	kmsan_check_memory(src, count * 4);
 	IO_COND(addr, outsl(port, src,count), mmio_outsl(addr, src, count));
 }
 EXPORT_SYMBOL(iowrite8_rep);
