diff --git a/include/exec/memory.h b/include/exec/memory.h
index 9f73b59..ea5d33a 100644
--- a/include/exec/memory.h
+++ b/include/exec/memory.h
@@ -3184,6 +3184,9 @@ bool ram_block_discard_is_disabled(void);
  */
 bool ram_block_discard_is_required(void);
 
+void ram_block_add_cpr_blocker(RAMBlock *rb, Error **errp);
+void ram_block_del_cpr_blocker(RAMBlock *rb);
+
 #endif
 
 #endif
diff --git a/include/exec/ramblock.h b/include/exec/ramblock.h
index 0babd10..64484cd 100644
--- a/include/exec/ramblock.h
+++ b/include/exec/ramblock.h
@@ -39,6 +39,7 @@ struct RAMBlock {
     /* RCU-enabled, writes protected by the ramlist lock */
     QLIST_ENTRY(RAMBlock) next;
     QLIST_HEAD(, RAMBlockNotifier) ramblock_notifiers;
+    Error *cpr_blocker;
     int fd;
     uint64_t fd_offset;
     int guest_memfd;
diff --git a/migration/savevm.c b/migration/savevm.c
index bc375db..85a3559 100644
--- a/migration/savevm.c
+++ b/migration/savevm.c
@@ -3315,12 +3315,14 @@ void vmstate_register_ram(MemoryRegion *mr, DeviceState *dev)
     qemu_ram_set_idstr(mr->ram_block,
                        memory_region_name(mr), dev);
     qemu_ram_set_migratable(mr->ram_block);
+    ram_block_add_cpr_blocker(mr->ram_block, &error_fatal);
 }
 
 void vmstate_unregister_ram(MemoryRegion *mr, DeviceState *dev)
 {
     qemu_ram_unset_idstr(mr->ram_block);
     qemu_ram_unset_migratable(mr->ram_block);
+    ram_block_del_cpr_blocker(mr->ram_block);
 }
 
 void vmstate_register_ram_global(MemoryRegion *mr)
diff --git a/system/physmem.c b/system/physmem.c
index 67c9db9..4ffa977 100644
--- a/system/physmem.c
+++ b/system/physmem.c
@@ -70,7 +70,10 @@
 
 #include "qemu/pmem.h"
 
+#include "qapi/qapi-types-migration.h"
+#include "migration/blocker.h"
 #include "migration/cpr.h"
+#include "migration/options.h"
 #include "migration/vmstate.h"
 
 #include "qemu/range.h"
@@ -1899,6 +1902,14 @@ static void ram_block_add(RAMBlock *new_block, Error **errp)
             qemu_mutex_unlock_ramlist();
             goto out_free;
         }
+
+        error_setg(&new_block->cpr_blocker,
+                   "Memory region %s uses guest_memfd, "
+                   "which is not supported with CPR.",
+                   memory_region_name(new_block->mr));
+        migrate_add_blocker_modes(&new_block->cpr_blocker, errp,
+                                  MIG_MODE_CPR_TRANSFER,
+                                  -1);
     }
 
     ram_size = (new_block->offset + new_block->max_length) >> TARGET_PAGE_BITS;
@@ -4059,3 +4070,60 @@ bool ram_block_discard_is_required(void)
     return qatomic_read(&ram_block_discard_required_cnt) ||
            qatomic_read(&ram_block_coordinated_discard_required_cnt);
 }
+
+/*
+ * Return true if ram is compatible with CPR.  Do not exclude rom,
+ * because the rom file could change in new QEMU.
+ */
+static bool ram_is_cpr_compatible(RAMBlock *rb)
+{
+    MemoryRegion *mr = rb->mr;
+
+    if (!mr || !memory_region_is_ram(mr)) {
+        return true;
+    }
+
+    /* Ram device is remapped in new QEMU */
+    if (memory_region_is_ram_device(mr)) {
+        return true;
+    }
+
+    /* Named files are remapped in new QEMU, same contents if shared (no COW) */
+    if (qemu_ram_is_shared(rb) && qemu_ram_is_named_file(rb)) {
+        return true;
+    }
+
+    /* A file descriptor is remapped in new QEMU */
+    if (rb->fd >= 0 && qemu_ram_is_shared(rb)) {
+        return true;
+    }
+
+    return false;
+}
+
+/*
+ * Add a blocker for each volatile ram block.  This function should only be
+ * called after we know that the block is migratable.  Non-migratable blocks
+ * are either re-created in new QEMU, or are handled specially, or are covered
+ * by a device-level CPR blocker.
+ */
+void ram_block_add_cpr_blocker(RAMBlock *rb, Error **errp)
+{
+    assert(qemu_ram_is_migratable(rb));
+
+    if (ram_is_cpr_compatible(rb)) {
+        return;
+    }
+
+    error_setg(&rb->cpr_blocker,
+               "Memory region %s is not compatible with CPR. share=on is "
+               "required for memory-backend objects, and aux-ram-share=on is "
+               "required.", memory_region_name(rb->mr));
+    migrate_add_blocker_modes(&rb->cpr_blocker, errp, MIG_MODE_CPR_TRANSFER,
+                              -1);
+}
+
+void ram_block_del_cpr_blocker(RAMBlock *rb)
+{
+    migrate_del_blocker(&rb->cpr_blocker);
+}
