diff --git a/hw/virtio/vhost-user.c b/hw/virtio/vhost-user.c
index 00561daa06..7b030ae2cd 100644
--- a/hw/virtio/vhost-user.c
+++ b/hw/virtio/vhost-user.c
@@ -24,6 +24,7 @@
 #include "qemu/main-loop.h"
 #include "qemu/uuid.h"
 #include "qemu/sockets.h"
+#include "qemu/lockable.h"
 #include "sysemu/runstate.h"
 #include "sysemu/cryptodev.h"
 #include "migration/postcopy-ram.h"
@@ -446,6 +447,10 @@ static int vhost_user_set_log_base(struct vhost_dev *dev, uint64_t base,
         .hdr.size = sizeof(msg.payload.log),
     };

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     /* Send only once with first queue pair */
     if (dev->vq_index != 0) {
         return 0;
@@ -664,6 +669,7 @@ static int send_remove_regions(struct vhost_dev *dev,
                                bool reply_supported)
 {
     struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
     struct vhost_memory_region *shadow_reg;
     int i, fd, shadow_reg_idx, ret;
     ram_addr_t offset;
@@ -685,6 +691,8 @@ static int send_remove_regions(struct vhost_dev *dev,
             vhost_user_fill_msg_region(&region_buffer, shadow_reg, 0);
             msg->payload.mem_reg.region = region_buffer;

+            QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
             ret = vhost_user_write(dev, msg, NULL, 0);
             if (ret < 0) {
                 return ret;
@@ -718,6 +726,7 @@ static int send_add_regions(struct vhost_dev *dev,
                             bool reply_supported, bool track_ramblocks)
 {
     struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
     int i, fd, ret, reg_idx, reg_fd_idx;
     struct vhost_memory_region *reg;
     MemoryRegion *mr;
@@ -746,6 +755,8 @@ static int send_add_regions(struct vhost_dev *dev,
             vhost_user_fill_msg_region(&region_buffer, reg, offset);
             msg->payload.mem_reg.region = region_buffer;

+            QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
             ret = vhost_user_write(dev, msg, &fd, 1);
             if (ret < 0) {
                 return ret;
@@ -893,6 +904,7 @@ static int vhost_user_set_mem_table_postcopy(struct vhost_dev *dev,
                                              bool config_mem_slots)
 {
     struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
     int fds[VHOST_MEMORY_BASELINE_NREGIONS];
     size_t fd_num = 0;
     VhostUserMsg msg_reply;
@@ -926,6 +938,8 @@ static int vhost_user_set_mem_table_postcopy(struct vhost_dev *dev,
             return ret;
         }

+        QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
         ret = vhost_user_write(dev, &msg, fds, fd_num);
         if (ret < 0) {
             return ret;
@@ -1005,6 +1019,7 @@ static int vhost_user_set_mem_table(struct vhost_dev *dev,
                                     struct vhost_memory *mem)
 {
     struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
     int fds[VHOST_MEMORY_BASELINE_NREGIONS];
     size_t fd_num = 0;
     bool do_postcopy = u->postcopy_listen && u->postcopy_fd.handler;
@@ -1044,6 +1059,8 @@ static int vhost_user_set_mem_table(struct vhost_dev *dev,
             return ret;
         }

+        QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
         ret = vhost_user_write(dev, &msg, fds, fd_num);
         if (ret < 0) {
             return ret;
@@ -1089,6 +1106,10 @@ static int vhost_user_get_u64(struct vhost_dev *dev, int request, uint64_t *u64)
         return 0;
     }

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         return ret;
@@ -1138,6 +1159,10 @@ static int vhost_user_write_sync(struct vhost_dev *dev, VhostUserMsg *msg,
         }
     }

+/*  struct vhost_user *u = dev->opaque;
+ *  struct VhostUserState *us = u->user;
+ *  QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+ */
     ret = vhost_user_write(dev, msg, NULL, 0);
     if (ret < 0) {
         return ret;
@@ -1277,6 +1302,8 @@ static int vhost_user_get_vring_base(struct vhost_dev *dev,
         .hdr.size = sizeof(msg.payload.state),
     };
     struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);

     VhostUserHostNotifier *n = fetch_notifier(u->user, ring->index);
     if (n) {
@@ -1669,6 +1696,9 @@ int vhost_user_get_shared_object(struct vhost_dev *dev, unsigned char *uuid,
     };
     memcpy(msg.payload.object.uuid, uuid, sizeof(msg.payload.object.uuid));

+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         return ret;
@@ -1889,6 +1919,9 @@ static int vhost_setup_backend_channel(struct vhost_dev *dev)
         msg.hdr.flags |= VHOST_USER_NEED_REPLY_MASK;
     }

+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, &sv[1], 1);
     if (ret) {
         goto out;
@@ -1993,6 +2026,9 @@ static int vhost_user_postcopy_advise(struct vhost_dev *dev, Error **errp)
         .hdr.flags = VHOST_USER_VERSION,
     };

+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         error_setg(errp, "Failed to send postcopy_advise to vhost");
@@ -2051,6 +2087,9 @@ static int vhost_user_postcopy_listen(struct vhost_dev *dev, Error **errp)

     trace_vhost_user_postcopy_listen();

+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         error_setg(errp, "Failed to send postcopy_listen to vhost");
@@ -2080,6 +2119,9 @@ static int vhost_user_postcopy_end(struct vhost_dev *dev, Error **errp)

     trace_vhost_user_postcopy_end_entry();

+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         error_setg(errp, "Failed to send postcopy_end to vhost");
@@ -2372,6 +2414,10 @@ static int vhost_user_net_set_mtu(struct vhost_dev *dev, uint16_t mtu)
         msg.hdr.flags |= VHOST_USER_NEED_REPLY_MASK;
     }

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         return ret;
@@ -2396,6 +2442,10 @@ static int vhost_user_send_device_iotlb_msg(struct vhost_dev *dev,
         .payload.iotlb = *imsg,
     };

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         return ret;
@@ -2428,6 +2478,10 @@ static int vhost_user_get_config(struct vhost_dev *dev, uint8_t *config,

     assert(config_len <= VHOST_USER_MAX_CONFIG_SIZE);

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     msg.payload.config.offset = 0;
     msg.payload.config.size = config_len;
     ret = vhost_user_write(dev, &msg, NULL, 0);
@@ -2492,6 +2546,10 @@ static int vhost_user_set_config(struct vhost_dev *dev, const uint8_t *data,
     p = msg.payload.config.region;
     memcpy(p, data, size);

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         return ret;
@@ -2570,6 +2628,10 @@ static int vhost_user_crypto_create_session(struct vhost_dev *dev,
         }
     }

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     msg.payload.session.op_code = backend_info->op_code;
     msg.payload.session.session_id = backend_info->session_id;
     ret = vhost_user_write(dev, &msg, NULL, 0);
@@ -2662,6 +2724,9 @@ static int vhost_user_get_inflight_fd(struct vhost_dev *dev,
         return 0;
     }

+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         return ret;
@@ -2757,6 +2822,7 @@ bool vhost_user_init(VhostUserState *user, CharBackend *chr, Error **errp)
     user->memory_slots = 0;
     user->notifiers = g_ptr_array_new_full(VIRTIO_QUEUE_MAX / 4,
                                            &vhost_user_state_destroy);
+    qemu_mutex_init(&user->vhost_user_request_reply_lock);
     return true;
 }

@@ -2769,6 +2835,7 @@ void vhost_user_cleanup(VhostUserState *user)
     user->notifiers = (GPtrArray *) g_ptr_array_free(user->notifiers, true);
     memory_region_transaction_commit();
     user->chr = NULL;
+    qemu_mutex_destroy(&user->vhost_user_request_reply_lock);
 }


@@ -2902,6 +2969,9 @@ static int vhost_user_set_device_state_fd(struct vhost_dev *dev,
         return -ENOTSUP;
     }

+    struct VhostUserState *us = vu->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, &fd, 1);
     close(fd);
     if (ret < 0) {
@@ -2965,6 +3035,10 @@ static int vhost_user_check_device_state(struct vhost_dev *dev, Error **errp)
         return -ENOTSUP;
     }

+    struct vhost_user *u = dev->opaque;
+    struct VhostUserState *us = u->user;
+    QEMU_LOCK_GUARD(&us->vhost_user_request_reply_lock);
+
     ret = vhost_user_write(dev, &msg, NULL, 0);
     if (ret < 0) {
         error_setg_errno(errp, -ret,
diff --git a/include/hw/virtio/vhost-user.h b/include/hw/virtio/vhost-user.h
index 324cd8663a..e96f12d449 100644
--- a/include/hw/virtio/vhost-user.h
+++ b/include/hw/virtio/vhost-user.h
@@ -67,6 +67,9 @@ typedef struct VhostUserState {
     GPtrArray *notifiers;
     int memory_slots;
     bool supports_config;
+
+    /* Hold lock for a request-reply cycle */
+    QemuMutex vhost_user_request_reply_lock;
 } VhostUserState;

 /**
