diff --git a/include/hw/pci/pci.h b/include/hw/pci/pci.h
index 44dacfa224..b54b6ef88f 100644
--- a/include/hw/pci/pci.h
+++ b/include/hw/pci/pci.h
@@ -16,6 +16,7 @@ extern bool pci_available;
 #define PCI_SLOT(devfn)         (((devfn) >> 3) & 0x1f)
 #define PCI_FUNC(devfn)         ((devfn) & 0x07)
 #define PCI_BUILD_BDF(bus, devfn)     ((bus << 8) | (devfn))
+#define PCI_BDF_TO_DEVFN(x)     ((x) & 0xff)
 #define PCI_BUS_MAX             256
 #define PCI_DEVFN_MAX           256
 #define PCI_SLOT_MAX            32
@@ -127,6 +128,10 @@ typedef void PCIMapIORegionFunc(PCIDevice *pci_dev, int region_num,
                                 pcibus_t addr, pcibus_t size, int type);
 typedef void PCIUnregisterFunc(PCIDevice *pci_dev);
 
+typedef void MSITriggerFunc(PCIDevice *dev, MSIMessage msg);
+typedef MSIMessage MSIPrepareMessageFunc(PCIDevice *dev, unsigned vector);
+typedef MSIMessage MSIxPrepareMessageFunc(PCIDevice *dev, unsigned vector);
+
 typedef struct PCIIORegion {
     pcibus_t addr; /* current PCI mapping address. -1 means not mapped */
 #define PCI_BAR_UNMAPPED (~(pcibus_t)0)
@@ -329,6 +334,14 @@ struct PCIDevice {
     /* Space to store MSIX table & pending bit array */
     uint8_t *msix_table;
     uint8_t *msix_pba;
+
+    /* May be used by INTx or MSI during interrupt notification */
+    void *irq_opaque;
+
+    MSITriggerFunc *msi_trigger;
+    MSIPrepareMessageFunc *msi_prepare_message;
+    MSIxPrepareMessageFunc *msix_prepare_message;
+
     /* MemoryRegion container for msix exclusive BAR setup */
     MemoryRegion msix_exclusive_bar;
     /* Memory Regions for MSIX table and pending bit entries. */
diff --git a/include/hw/remote/vfio-user-obj.h b/include/hw/remote/vfio-user-obj.h
new file mode 100644
index 0000000000..87ab78b875
--- /dev/null
+++ b/include/hw/remote/vfio-user-obj.h
@@ -0,0 +1,6 @@
+#ifndef VFIO_USER_OBJ_H
+#define VFIO_USER_OBJ_H
+
+void vfu_object_set_bus_irq(PCIBus *pci_bus);
+
+#endif
diff --git a/hw/pci/msi.c b/hw/pci/msi.c
index 47d2b0f33c..d556e17a09 100644
--- a/hw/pci/msi.c
+++ b/hw/pci/msi.c
@@ -134,7 +134,7 @@ void msi_set_message(PCIDevice *dev, MSIMessage msg)
     pci_set_word(dev->config + msi_data_off(dev, msi64bit), msg.data);
 }
 
-MSIMessage msi_get_message(PCIDevice *dev, unsigned int vector)
+static MSIMessage msi_prepare_message(PCIDevice *dev, unsigned int vector)
 {
     uint16_t flags = pci_get_word(dev->config + msi_flags_off(dev));
     bool msi64bit = flags & PCI_MSI_FLAGS_64BIT;
@@ -159,6 +159,11 @@ MSIMessage msi_get_message(PCIDevice *dev, unsigned int vector)
     return msg;
 }
 
+MSIMessage msi_get_message(PCIDevice *dev, unsigned int vector)
+{
+    return dev->msi_prepare_message(dev, vector);
+}
+
 bool msi_enabled(const PCIDevice *dev)
 {
     return msi_present(dev) &&
@@ -241,6 +246,8 @@ int msi_init(struct PCIDevice *dev, uint8_t offset,
                      0xffffffff >> (PCI_MSI_VECTORS_MAX - nr_vectors));
     }
 
+    dev->msi_prepare_message = msi_prepare_message;
+
     return 0;
 }
 
@@ -256,6 +263,7 @@ void msi_uninit(struct PCIDevice *dev)
     cap_size = msi_cap_sizeof(flags);
     pci_del_capability(dev, PCI_CAP_ID_MSI, cap_size);
     dev->cap_present &= ~QEMU_PCI_CAP_MSI;
+    dev->msi_prepare_message = NULL;
 
     MSI_DEV_PRINTF(dev, "uninit\n");
 }
@@ -334,11 +342,7 @@ void msi_notify(PCIDevice *dev, unsigned int vector)
 
 void msi_send_message(PCIDevice *dev, MSIMessage msg)
 {
-    MemTxAttrs attrs = {};
-
-    attrs.requester_id = pci_requester_id(dev);
-    address_space_stl_le(&dev->bus_master_as, msg.address, msg.data,
-                         attrs, NULL);
+    dev->msi_trigger(dev, msg);
 }
 
 /* Normally called by pci_default_write_config(). */
diff --git a/hw/pci/msix.c b/hw/pci/msix.c
index ae9331cd0b..6f85192d6f 100644
--- a/hw/pci/msix.c
+++ b/hw/pci/msix.c
@@ -31,7 +31,7 @@
 #define MSIX_ENABLE_MASK (PCI_MSIX_FLAGS_ENABLE >> 8)
 #define MSIX_MASKALL_MASK (PCI_MSIX_FLAGS_MASKALL >> 8)
 
-MSIMessage msix_get_message(PCIDevice *dev, unsigned vector)
+static MSIMessage msix_prepare_message(PCIDevice *dev, unsigned vector)
 {
     uint8_t *table_entry = dev->msix_table + vector * PCI_MSIX_ENTRY_SIZE;
     MSIMessage msg;
@@ -41,6 +41,11 @@ MSIMessage msix_get_message(PCIDevice *dev, unsigned vector)
     return msg;
 }
 
+MSIMessage msix_get_message(PCIDevice *dev, unsigned vector)
+{
+    return dev->msix_prepare_message(dev, vector);
+}
+
 /*
  * Special API for POWER to configure the vectors through
  * a side channel. Should never be used by devices.
@@ -344,6 +349,8 @@ int msix_init(struct PCIDevice *dev, unsigned short nentries,
                           "msix-pba", pba_size);
     memory_region_add_subregion(pba_bar, pba_offset, &dev->msix_pba_mmio);
 
+    dev->msix_prepare_message = msix_prepare_message;
+
     return 0;
 }
 
@@ -429,6 +436,7 @@ void msix_uninit(PCIDevice *dev, MemoryRegion *table_bar, MemoryRegion *pba_bar)
     g_free(dev->msix_entry_used);
     dev->msix_entry_used = NULL;
     dev->cap_present &= ~QEMU_PCI_CAP_MSIX;
+    dev->msix_prepare_message = NULL;
 }
 
 void msix_uninit_exclusive_bar(PCIDevice *dev)
diff --git a/hw/pci/pci.c b/hw/pci/pci.c
index a9b37f8000..435f84393c 100644
--- a/hw/pci/pci.c
+++ b/hw/pci/pci.c
@@ -317,6 +317,15 @@ void pci_device_deassert_intx(PCIDevice *dev)
     }
 }
 
+static void pci_msi_trigger(PCIDevice *dev, MSIMessage msg)
+{
+    MemTxAttrs attrs = {};
+
+    attrs.requester_id = pci_requester_id(dev);
+    address_space_stl_le(&dev->bus_master_as, msg.address, msg.data,
+                         attrs, NULL);
+}
+
 static void pci_reset_regions(PCIDevice *dev)
 {
     int r;
@@ -1212,6 +1221,8 @@ static void pci_qdev_unrealize(DeviceState *dev)
 
     pci_device_deassert_intx(pci_dev);
     do_pci_unregister_device(pci_dev);
+
+    pci_dev->msi_trigger = NULL;
 }
 
 void pci_register_bar(PCIDevice *pci_dev, int region_num,
@@ -2251,6 +2262,8 @@ static void pci_qdev_realize(DeviceState *qdev, Error **errp)
     }
 
     pci_set_power(pci_dev, true);
+
+    pci_dev->msi_trigger = pci_msi_trigger;
 }
 
 PCIDevice *pci_new_multifunction(int devfn, bool multifunction,
diff --git a/hw/remote/machine.c b/hw/remote/machine.c
index 645b54343d..75d550daae 100644
--- a/hw/remote/machine.c
+++ b/hw/remote/machine.c
@@ -23,6 +23,8 @@
 #include "hw/remote/iommu.h"
 #include "hw/qdev-core.h"
 #include "hw/remote/iommu.h"
+#include "hw/remote/vfio-user-obj.h"
+#include "hw/pci/msi.h"
 
 static void remote_machine_init(MachineState *machine)
 {
@@ -54,12 +56,16 @@ static void remote_machine_init(MachineState *machine)
 
     if (s->vfio_user) {
         remote_iommu_setup(pci_host->bus);
-    }
 
-    remote_iohub_init(&s->iohub);
+        msi_nonbroken = true;
+
+        vfu_object_set_bus_irq(pci_host->bus);
+    } else {
+        remote_iohub_init(&s->iohub);
 
-    pci_bus_irqs(pci_host->bus, remote_iohub_set_irq, remote_iohub_map_irq,
-                 &s->iohub, REMOTE_IOHUB_NB_PIRQS);
+        pci_bus_irqs(pci_host->bus, remote_iohub_set_irq, remote_iohub_map_irq,
+                     &s->iohub, REMOTE_IOHUB_NB_PIRQS);
+    }
 
     qbus_set_hotplug_handler(BUS(pci_host->bus), OBJECT(s));
 }
diff --git a/hw/remote/vfio-user-obj.c b/hw/remote/vfio-user-obj.c
index ee28a93782..eeb165a805 100644
--- a/hw/remote/vfio-user-obj.c
+++ b/hw/remote/vfio-user-obj.c
@@ -53,6 +53,9 @@
 #include "hw/pci/pci.h"
 #include "qemu/timer.h"
 #include "exec/memory.h"
+#include "hw/pci/msi.h"
+#include "hw/pci/msix.h"
+#include "hw/remote/vfio-user-obj.h"
 
 #define TYPE_VFU_OBJECT "x-vfio-user-server"
 OBJECT_DECLARE_TYPE(VfuObject, VfuObjectClass, VFU_OBJECT)
@@ -96,6 +99,10 @@ struct VfuObject {
     Error *unplug_blocker;
 
     int vfu_poll_fd;
+
+    MSITriggerFunc *default_msi_trigger;
+    MSIPrepareMessageFunc *default_msi_prepare_message;
+    MSIxPrepareMessageFunc *default_msix_prepare_message;
 };
 
 static void vfu_object_init_ctx(VfuObject *o, Error **errp);
@@ -520,6 +527,111 @@ static void vfu_object_register_bars(vfu_ctx_t *vfu_ctx, PCIDevice *pdev)
     }
 }
 
+static int vfu_object_map_irq(PCIDevice *pci_dev, int intx)
+{
+    int pci_bdf = PCI_BUILD_BDF(pci_bus_num(pci_get_bus(pci_dev)),
+                                pci_dev->devfn);
+
+    return pci_bdf;
+}
+
+static void vfu_object_set_irq(void *opaque, int pirq, int level)
+{
+    PCIBus *pci_bus = opaque;
+    PCIDevice *pci_dev = NULL;
+    vfu_ctx_t *vfu_ctx = NULL;
+    int pci_bus_num, devfn;
+
+    if (level) {
+        pci_bus_num = PCI_BUS_NUM(pirq);
+        devfn = PCI_BDF_TO_DEVFN(pirq);
+
+        /*
+         * pci_find_device() performs at O(1) if the device is attached
+         * to the root PCI bus. Whereas, if the device is attached to a
+         * secondary PCI bus (such as when a root port is involved),
+         * finding the parent PCI bus could take O(n)
+         */
+        pci_dev = pci_find_device(pci_bus, pci_bus_num, devfn);
+
+        vfu_ctx = pci_dev->irq_opaque;
+
+        g_assert(vfu_ctx);
+
+        vfu_irq_trigger(vfu_ctx, 0);
+    }
+}
+
+static MSIMessage vfu_object_msi_prepare_msg(PCIDevice *pci_dev,
+                                             unsigned int vector)
+{
+    MSIMessage msg;
+
+    msg.address = 0;
+    msg.data = vector;
+
+    return msg;
+}
+
+static void vfu_object_msi_trigger(PCIDevice *pci_dev, MSIMessage msg)
+{
+    vfu_ctx_t *vfu_ctx = pci_dev->irq_opaque;
+
+    vfu_irq_trigger(vfu_ctx, msg.data);
+}
+
+static void vfu_object_setup_msi_cbs(VfuObject *o)
+{
+    o->default_msi_trigger = o->pci_dev->msi_trigger;
+    o->default_msi_prepare_message = o->pci_dev->msi_prepare_message;
+    o->default_msix_prepare_message = o->pci_dev->msix_prepare_message;
+
+    o->pci_dev->msi_trigger = vfu_object_msi_trigger;
+    o->pci_dev->msi_prepare_message = vfu_object_msi_prepare_msg;
+    o->pci_dev->msix_prepare_message = vfu_object_msi_prepare_msg;
+}
+
+static void vfu_object_restore_msi_cbs(VfuObject *o)
+{
+    o->pci_dev->msi_trigger = o->default_msi_trigger;
+    o->pci_dev->msi_prepare_message = o->default_msi_prepare_message;
+    o->pci_dev->msix_prepare_message = o->default_msix_prepare_message;
+}
+
+static int vfu_object_setup_irqs(VfuObject *o, PCIDevice *pci_dev)
+{
+    vfu_ctx_t *vfu_ctx = o->vfu_ctx;
+    int ret;
+
+    ret = vfu_setup_device_nr_irqs(vfu_ctx, VFU_DEV_INTX_IRQ, 1);
+    if (ret < 0) {
+        return ret;
+    }
+
+    if (msix_nr_vectors_allocated(pci_dev)) {
+        ret = vfu_setup_device_nr_irqs(vfu_ctx, VFU_DEV_MSIX_IRQ,
+                                       msix_nr_vectors_allocated(pci_dev));
+    } else if (msi_nr_vectors_allocated(pci_dev)) {
+        ret = vfu_setup_device_nr_irqs(vfu_ctx, VFU_DEV_MSI_IRQ,
+                                       msi_nr_vectors_allocated(pci_dev));
+    }
+
+    if (ret < 0) {
+        return ret;
+    }
+
+    vfu_object_setup_msi_cbs(o);
+
+    pci_dev->irq_opaque = vfu_ctx;
+
+    return 0;
+}
+
+void vfu_object_set_bus_irq(PCIBus *pci_bus)
+{
+    pci_bus_irqs(pci_bus, vfu_object_set_irq, vfu_object_map_irq, pci_bus, 1);
+}
+
 /*
  * TYPE_VFU_OBJECT depends on the availability of the 'socket' and 'device'
  * properties. It also depends on devices instantiated in QEMU. These
@@ -632,6 +744,13 @@ static void vfu_object_init_ctx(VfuObject *o, Error **errp)
 
     vfu_object_register_bars(o->vfu_ctx, o->pci_dev);
 
+    ret = vfu_object_setup_irqs(o, o->pci_dev);
+    if (ret < 0) {
+        error_setg(errp, "vfu: Failed to setup interrupts for %s",
+                   o->device);
+        goto fail;
+    }
+
     ret = vfu_realize_ctx(o->vfu_ctx);
     if (ret < 0) {
         error_setg(errp, "vfu: Failed to realize device %s- %s",
@@ -657,6 +776,8 @@ fail:
         o->unplug_blocker = NULL;
     }
     if (o->pci_dev) {
+        vfu_object_restore_msi_cbs(o);
+        o->pci_dev->irq_opaque = NULL;
         object_unref(OBJECT(o->pci_dev));
         o->pci_dev = NULL;
     }
@@ -716,6 +837,8 @@ static void vfu_object_finalize(Object *obj)
     }
 
     if (o->pci_dev) {
+        vfu_object_restore_msi_cbs(o);
+        o->pci_dev->irq_opaque = NULL;
         object_unref(OBJECT(o->pci_dev));
         o->pci_dev = NULL;
     }
diff --git a/stubs/vfio-user-obj.c b/stubs/vfio-user-obj.c
new file mode 100644
index 0000000000..79100d768e
--- /dev/null
+++ b/stubs/vfio-user-obj.c
@@ -0,0 +1,6 @@
+#include "qemu/osdep.h"
+#include "hw/remote/vfio-user-obj.h"
+
+void vfu_object_set_bus_irq(PCIBus *pci_bus)
+{
+}
diff --git a/MAINTAINERS b/MAINTAINERS
index 9d8695b68d..844ed75834 100644
--- a/MAINTAINERS
+++ b/MAINTAINERS
@@ -3604,6 +3604,7 @@ F: hw/remote/iohub.c
 F: include/hw/remote/iohub.h
 F: subprojects/libvfio-user
 F: hw/remote/vfio-user-obj.c
+F: include/hw/remote/vfio-user-obj.h
 F: hw/remote/iommu.c
 F: include/hw/remote/iommu.h
 
diff --git a/hw/remote/trace-events b/hw/remote/trace-events
index 847d50d88f..c167b3c7a5 100644
--- a/hw/remote/trace-events
+++ b/hw/remote/trace-events
@@ -12,3 +12,4 @@ vfu_dma_unregister(uint64_t gpa) "vfu: unregistering GPA 0x%"PRIx64""
 vfu_bar_register(int i, uint64_t addr, uint64_t size) "vfu: BAR %d: addr 0x%"PRIx64" size 0x%"PRIx64""
 vfu_bar_rw_enter(const char *op, uint64_t addr) "vfu: %s request for BAR address 0x%"PRIx64""
 vfu_bar_rw_exit(const char *op, uint64_t addr) "vfu: Finished %s of BAR address 0x%"PRIx64""
+vfu_interrupt(int pirq) "vfu: sending interrupt to device - PIRQ %d"
diff --git a/stubs/meson.build b/stubs/meson.build
index 6f80fec761..d8f3fd5c44 100644
--- a/stubs/meson.build
+++ b/stubs/meson.build
@@ -60,3 +60,4 @@ if have_system
 else
   stub_ss.add(files('qdev.c'))
 endif
+stub_ss.add(when: 'CONFIG_VFIO_USER_SERVER', if_false: files('vfio-user-obj.c'))
